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KMID : 1134820140430020318
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 2 p.318 ~ p.322
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Inhibitory Effect of Curcuma longa L. Extracts on 5-Alpha Reductase Ⅱ Activity
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Kim Jong-Yeon
Lee Jeong-Yoon
Yoon Ho-Geun
Kim Yong-Jae
Jun Woo-Jin
Hwang Kwon-Tack
Cha Min-Seok
Lee Yoo-Hyun
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Abstract
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5-Alpha reductase Ⅱ, which converts testosterone (T) to dihydrotestosterone (DHT), is a crucial enzyme Ⅱ in benign prostatic hyperplasia. Inhibitory effects of Curcuma longa L. (CL) extracts on 5-alpha reductase Ⅱ activity were investigated in rat prostate tissue homogenates as well as LNCaP cells expressing human 5-alpha reductase Ⅱ. Hot water extract (CL-HW) of Curcuma longa L. significantly inhibited 5-alpha reductase activity by over 80% at a concentration of 100 μg/mL, whereas 20% ethanol extracts (CL-E20) of Curcuma longa L. exhibited significant inhibitory activity from 50 μg/mL. These results indicated that Curcuma longa L is a potent 5-alpha reductase Ⅱ inhibitor for benign prostatic hyperplasia treatment.
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KEYWORD
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Curcuma longa L., benign prostate hyperplasia, 5-alpha reductase Ⅱ, dihydrotestosterone
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